Division of Applied Mechanics, Technology of Materials and Biomechanics
(Director: Lampeas George)
Members: Sotiriadis Georgios-Alexandros, Karvelis Stefanos, Apostolopoulos Konstantinos, Mihanetzis George, Lampeas George, Loutas Theodoros
Area of expertise
The research activities of the Section are focused on leading technical areas such as, aerospace materials and aerostructures, composite materials, wind-turbine rotor structures, nanomaterials and nanomechanics, advanced computational mechanics, bio- and tissue-engineering, NDT, structural health monitoring and smart materials. The majority of conducted research receives competitive funding from national and EU sources, thus maintaining direct interactions with European Universities, Research Centers and Industry. The research works of the Section are internationally renowned through publications in referred journals, the authoring of books published by international publishers, presentations in international conferences, and organization of international conferences.
- Τηλέφωνο: 2610 997233/7172
Διευθυντής: Loutas Theodoros
Μέλη: Polyzos Demosthenes, Saravanos Dimitris, Philippidis Theodore, Chrysochoidis Nikolaos, Sotiriadis Georgios-Alexandros
- Website: http://ltsm.mead.upatras.gr/Email: pantelak@mech.upatras.grΤηλέφωνο: 2610 969498
Διευθυντής: Tserpes Konstantinos
Μέλη: Tserpes Konstantinos, Lampeas George, Apostolopoulos Konstantinos, Polatidis Efthymios, Karvelis Stefanos
Subject of the Laboratory of Technology and Strength of materials is the education of undergraduate and post-graduate students on science and on technology of materials, strength of materials and components of engineering structures, as well as conducting fundamental and applied research on the above scientific fields. Concerning education, LTSM offers courses specialized in science and technology of materials, mechanical behavior of materials, strength of materials and structural components, fracture mechanics, structural analysis and structural integrity.
Concerning research, LTSM performs high quality research on development and characterization of materials, strength evaluation of structural components, as well as analysis and design of aeronautical structures. LTSM participates in a big number of national and European competitive research programs, mostly related to aeronautics, and has been established as focal point in Greece in terms of research on aeronautical materials and structures.
With reference to both education and research, LTSM has developed strong links with all leading Universities and aeronautics research centers in Greece and abroad, as well as all major aerospace and aircraft industries worldwide.
Finally referring to the sector of industrial services, LTSM affords equipment, human resources and long experience in mechanical testing, structural integrity mechanical behavior of materials and structures, structural analysis.
Teaching
LTSM provides the following cources:
Undergraduate studies:
1) Materials science I,II
2) Strength of materials I,II
3) Mechanical behavior of materials
4) Aeronautical materials
5) Aeronautical structure analysis I,II
6) Fatigue of aeronautical structures
7) Fracture Mechanics
8) Metallic structure analysis
9) Analysis of limit loads
10) Technology of polymer and composite materials
Post-graduate studies :
1) Structural integrity
2) State of the art technologies in Materials Science
3) Advanced Strength of materials
Research
Recent activities of the Laboratory of Technology and Strength of Materials extend to the following scientific areas:
- Science and technology of materials (development of new materials and their production technologies, materials characterization and certification, experimental characterization and simulation of the mechanical behavior of materials and structures),
- Strength of materials and structural components (determination of strength of metallic and composite materials, nano- materials and structural parts made of the pre mentioned materials),
- Structural analysis (stress analysis, evaluation of structural integrity and impact strength, structural optimisation),
- Design of aeronautical structures based on damage tolerance
- Fracture mechanics
- Damage Mechanics
Research activities of LTSM spread in the whole range of mechanical engineering applications with emphasis on aeronautics. Research is mainly conducted mainly in the frame of European competitive research programs.
Recent programs :
- Aeronautical Application of Wrought Magnesium (AEROMAG), CEC, STREP, 2005-2007.
- Non-Linear Multiscale Analysis of Large Aero-Structures (MUSCA), CEC, STREP, 2005-2007.
- Modular Joints of Aircraft Composite Structures (MOJO), EC, 2006-2009.
- Cellular Structures for Impact Performance (CELPACT), EC, 2006-2009.
- More Affordable Aircraft Through Extended, Integrated & Mature Numerical Sizing (MAAXIMUS), EU FP7, 2008-2013.
- Simulation Based Solutions for Industrial Manufacture of Large Infusion Composite Parts (INFUCOMP), EU FP7, 2008-2013.
- Cost Effective Reinforcement of Fastener Areas in Composites (CERFAC), EU FP7, 2010-2014.
- Extended Non-Destructive Testing for Composite Bonds (ENCOMB), EU FP7, 2010-2014.
- Innovative Manufacturing of Complicated Ti Components (INMA), EU FP7, 2010-2014.
- Smart Aircraft in Emergency Situation (SMAES), EU FP7, 2010-2014.
Since 2002, LTSM coordinates the European Aeronautics Science Network (EASN). Subject of EASN is to support and upgrade the research activities of the European Aeronautics Universities, as well as to facilitate them to respond to their key role within the European Aeronautical research Community in incubating new knowledge and breakthrough technologies. Members of this network are Professors of the most significant Universities across Europe.
Research obtained at LTSM are published in peer review scientific journals and presented at international conferences. During the last decade more than 180 publications were made by LTSM members.
Recent puplications are:
- K.I. Tserpes, P. Papanikos, G.N. Labeas, Sp.G. Pantelakis. Multi-scale modeling of tensile behaviour of carbon nanotube-reinforced composites. Theoretical & Applied Fracture Mechanic, 2008, 49, 51-60.
- Sp.G.Pantelakis, Ch.V.Katsiropoulos, G.N.Labeas, H. Sibois ”A concept to optimize quality and cost in thermoplastic composite components applied to the production of helicopter canopies”, Journal of Composites: Part A (40), 2009, p.p. 595-606.
- G. N. Labeas, Diamantakos, I., Kermanidis, Th.
Assessing the effect of residual stresses on the fatigue behavior of integrally stiffened structures. Theoretical and Applied Fracture Mechanics, 2009, 51(2), 2009, 95-101.
- K.I. Tserpes, G.N. Labeas. ‘Mesomechanical analysis of Non-Crimp Fabric Composite Structural Parts. Composite Structures, 2009, 87(4), 358-369.
- Ll. Llopart P., Tserpes, K.I., Labeas, G.N.
Experimental and theoretical investigation of the influence of imperfect bonding on the strength of NCF double-lap shears joints. CompositeStructures, 2009, 92, 1673-1682.
- G. Moraitis and G. Labeas. Prediction of residual stresses and distortions due to laser beam welding of butt joints in pressure vessels. International Journal of Pressure Vessels and Piping, 2009, 86, 133-142.
- A.N. Chamos, Sp.G. Pantelakis, V. Spiliadis.
Fatigue behaviour of bare and pre-corroded magnesium alloy AZ31. Materials & Design, 2010, 31, 4130-4137.
- A.T. Kermanidis, A.D. Zervaki, G.N. Haidemenopoulos, Sp.G. Pantelakis. The influence of salt fog exposure on the fatigue performance of alclad 6xxx aluminum alloys laser beam welded joints. Journal of Materials Science, 2010, 45, 4390-4400.
- A.N. Chamos, C.A. Charitidis, A. Skarmoutsou, Sp.G. Pantelakis. An investigation on the high stress sensitivity of fatigue life of rolled AZ31 magnesium alloy under constant amplitude fatigue loading, Fatigue & Fracture of Engineering Materials & Structures (FFEMS), 2010, 33, 252-265.
- G.N. Labeas, M.M. Sunaric. Investigation on the static response and failure process of metallic open lattice cellular structures. Strain, 2010, 46(2), 195-204.
- K.I. Tserpes, R. Ruzek, Sp. Pantelakis. ”Strength of Pi-shaped non-crimp fabric adhesively bonded joints”, accepted for publication in Plastics, Rubber and Composites Journal.
In recent years, LTSM has organized the following conferences :
- 6th International Conference on Mesomechanics 2004, Patras 2004.
- 3th National Conference of Metallic Materials, Patras 2007.
- 1st International Conference of Engineering Against Fracture (ICEAF I), Patras 2008.
- 2nd International Conference of Engineering Against Fracture (ICEAF II), Mykonos 2011.
During the last two decades, more than 20 doctorate thesies have been successfully carried out at LTSM.
Equipment
- UNIVERSAL TESTING MACHINE 200kN: Displacement rate can be varied from 0.015 – 500 mm/min.
- 2 FATIGUE TESTING MACHINES MTS (250kN & 100kN): Servo-hydraulic machines with frequency range up to 104 Hz suitable for fatigue testing under constant or variable load, for evaluation of characteristic fracture properties (KIC, COD) and for tensile tests under dynamic monotonic loading. The 250 KN machine is equipped with environmental chamber for testing at temperatures ranging from -100 to 400 0C.
- TORSION/BENDING FATIGUE TESTING MACHINE (160kNm)
- COMPRESSION TESTING MACHINE (2500kN): Suitable for testing construction materials and for structural components compression testing.
- 4 CREEP MACHINES: Suitable for creep testing up to 1000 0C.
- INSTRON IMPACT TEST MACHINE (Dynatup drop tower)
- SPLIT HOPKINSON BARS: Suitable for high strain rate tensile and compression tests (>103/sec)
- 2 MOBILE UNITS FOR STRAIN MEASUREMENTS
- CHAMBER FOR ACCELERATED SALT SPRAY TESTS
- EQUIPMENT FOR ACCELERATED CORROSION TESTS: a) immersion, b) alternate immersion, c) exfoliation corrosion
- 4 STRESS CORROSION CRACKING DEVICES (in-house developed): the devices are equipped with automated system of alternate immersion.
- HIGH RESOLUTION DIGITAL CAMERA OPTICAL SYSTEM FOR CRACK DETECTION AND CRACK MEASUREMENT: Suitable for crack growth measurements under monotonic and fatigue loading as well as for multi-site damage detection.
- METALLOGRAPHY LABORATORY: optical microscope, mobile unit for digital stereoscopic capturing of fracture surfaces, grinding and polishing equipment).
- HARDNESS AND MICROHARDNESS TEST MACHINES
- NON-DESTRUCTIVE TESTING UNIT (C-SCAN, A-SCAN, acoustic emission, eddie current, potential drop)
- MOBILE UNIT OF SURFACE TREATMENT (Ultrasonic Impact Treatment 27KHz)
- PORTABLE SURFACE TREATMENT DEVICE ADJUSTABLE TO CNC(Ultrasonic Impact Machining)
- PORTABLE DEVICE FOR RESIDUAL STRESS MEASUREMENTS (Open hole drilling)
- EQUIPMENT FOR CRACK GROWTH MEASUREMENTS WITH REPLICATION TECHNIQUE (up to 10μm)
- THERMAL TREATMENT CHAMBER (1100 0C)
- MACHINE SHOP (1 Lathe, 1 CNC cutting machine)
- Email: deligian@mech.upatras.grΤηλέφωνο: 2610 969460
The Laboratory of Biomechanics and Biomedical Engineering of the University of Patras has more than 25 years of experience in the fields of biomechanics and biomaterials emphasizing in the domain of cell-material interactions.
Blood compatibility testing using static and dynamic blood-material contact, cell-materila interactions in the case of diffenrent cell cultures, mechanical properties of cells, tissues and biomaterials are some of the main research interests of our group.
More recently nanotechnology and nanoidentation techniques, functionalization of polymeric surfaces via selected biomolecules immobilization techniques as well as techniques to study endothelial cell culture on biomaterials under dynamic (flow, mechanical stress) conditions have been developed.
Teaching
CHEMISTRY (1st year of studies)
BIOMECHANICS (section of applied mechanics and biomechanics): studying the mechanics of living organisms
BIOMATERIALS (section of apllied mechanics and biomechanics): studying materials that come from living organisms and materials that can work in living organisms
ARTIFICIAL ORGANS (section of applied mechanics and biomechanics): studying the design of artificial systems that can substitute totally or partially the function of the living organism systems
Research
Recent research projects:
2004-2008: COST Action 537, EEC,: Core Laboratories for the Improvement of Medical Devices in Clinical Practice from the Failure of the Explanted Prostheses Analysis (FEPA)
2005-2007: Project Pythagoras II “Expression and role of proteoglycans in the differentiation of osteoblastic progenetor cells”
2005-2008: Project STREP VASCUPLUG of the EEC: “Bioreactive Composite Scaffold Design for Improved Vascular Connexion of Tissue Engineered Products”
2006-2008: Project INTERREG between Greece and Italy: “Applied Biomaterials”
2006-2009: Project Karatheodoris: Biomechanics and biocompatibility of biomaterials applied in histotechnology.
2009-2013: FP7 Nanoparticles for Therapy and Diagnosis of Alzheimer Disease
2010-2011 : Project IKYDA 2010Greece-Germany: “Histotechnology of Biomaterials”
2010-2011: Project IKYDA 2010Greece-Germany:”Combination of biomimetic surface coatings and mechanical forces to control the differentiation of human embryonic cells”
2010-2013: Project Synergasia :”Nano-arthro-chondros”
2010-2013: Project Synergasia :”BIOMINY”
2012-2014: Project LEADERA: e-iliza-Development of an e-health system in orthopedics
2012-2016: Project FP7-people-ITN/Marie Curie “TECAS” tissue engineering of vardiovascular implants.
Selected Publications:
M. Katsikogianni and Y.F. Missirlis, “Concise review of mechanisms of bacterial adhesion to biomaterials and of techniques used in estimating bacteria-material interactions”, European Cells & Materials Journal,8, 37-57,2004
G. Koromila, GPA Michanetzis, YF Missirlis and SG Antimisiaris. Heparin incorporating liposomes as a delivery system of heparin from PET-covered metallic stents: Effect on haemocompatibility. Biomaterials, Volume 27, I12, 2006, p. 2525-2533
M. Itskov, A. E. Ehret, and D. Mavrilas. “A polyconvex anisotropic strain energy function for soft biological tissues” Biomech Model Mechanbiol 5; 17-26 (2006).
D.. Mavrilas, P.G. Koutsoukos, E.N. Koletsis, E. Apostolakis, D. Dougenis. “In-vitro evaluation for potential calcification of biomaterials used for staple line reinforcement in lung surgery ” Experimental Biology & Medicine 231; 1712-1717 (2006).
Katsikogianni M. G., Syndrevelis C. S., Amanatides E., Mataras D. S., Missirlis Y. F., “Plasma treated and a-C:H coated PET performance in inhibiting bacterial adhesion”, Plasma Processes and Polymers, 4( S1), : S1046-S1051 ,2007
Th. S. Tsapikouni and Y.F.Missirlis, “pH and ionic strength effect on single fibrinogen molecule adsorption on mica studied with AFM”, Colloids and Surfaces B: Biointerfaces, 57, (1) : 89-96, 2007
Moutzouri A., Skoutelis A., Gogos H., Missirlis Y., Athanassiou G. ” Red blood cell deformability in patients with sepsis: A marker for prognosis and monitoring of severity” Clinical Hemorheology and Microcirculation, 36 (2007) 291-299.
DD Deligianni and CA Apostolopoulos. Multilevel finite element modeling for the prediction of local cellular deformation in bone. Biomech ModelMechanobiol 7(2), 2008, 151-9. Epub 2007 Apr 13.
GPAK Michanetzis, YF Missirlis and SG Antimisiaris. Haemocompatibility of nanosized drug delivery systems: Has it been adequately concidered? Journal of Biomedical Nanotechnology, V4, 2008, p 218-233.
Moutzouri A., Athanassiou G., Gogos C., “Red blood cells deformability from patients with Diabettes” Journal Infection Feb-2008.
CA Apostolopoulos and DD Deligianni. Prediction of local cellular deformation in bone-Influence of microstructure dimensions. Journal of Neuronal and Musculoskeletal Interactions Interactions 9(2), 2009, 99-108.
M. Krings, D. Kanellopoulou, P.G. Koutsoukos, D. Mavrilas, B. Glasmacher: “Development of a new combined test set-up for accelerated dynamic pH controlled in vitro calcification of porcine heart valves”. Int. J for Artificial Organs 32(11); 794-801(2009).
P Kokkinos, I. Zarkadis, T. Panidia and D. Deligianni. Estimation of hydrodynamic shear stresses developed on human osteoblasts cultured on Ti-6Al-4V and strained by four point bending. Effects of mechanical loading to specific gene expression. Journal of Materials Science: Materials in Medicine 20, 2009, 655-65.
Stergios Dermenoudis and Yannis Missirlis, “Design of a novel rotating wall bioreactor for the in vitro simulation of the mechanical environment of the endothelial function “, J.Biomechanics, 43(7):1426-1431,2010
Th. S. Tsapikouni and Y.F.Missirlis, “Measuring the force of single protein molecule detachment from surfaces with AFM”, Colloids and Surfaces B: Biointerfaces, 75(1): 252-259,2010.
M.G. Katsikogianni, Y.F. Missirlis, “Bacterial adhesion onto materials with specific surface chemistries under flow conditions”, J. of Materials Science: Materials in Medicine , 21:963-968, 2010.
Kaleridis V., Athanassiou G., Deligianni D., Missirlis Y. “Effects of nucleus in leukocyte deformability at slow deformation rates” Clinical Hemorheology 45(1) 53-65, 2010 .
S.I. Gkizas, E. Apostolakis, E. Pagoulatou, D. Mavrilas, D.J. Papachristou, E. Koletsis, A. Papalois, H. Papadaki, D. Alexopoulos “Aldosterone receptor inhibition alters the viscoelastic biomechanical behavior of the aortic wall” Experimental Biology & Medicine 235;311-316 (2010).
S. Dermenoudis and Y.F.Missirlis, ” Bioreactors in Tissue Engineering”. Invited Review in Advanced Biomaterials, 2010.
A.Soininen, J.Levon, M.Katsikogianni, K.Myllymaa, R .Lappalainen, Y.T.Konttinen, T.J.Kinnari, V.-M.Tiainen,Y.Missirlis, ” In vitro adhesion of staphylococci to diamond-like carbon polymer hybrids under dynamic flow conditions” J Mater Sci: Mater Med, 22(3): 629-636, 2011
Th.Tsapikouni and Y.F.Missirlis, “P-selectin /ligand unbinding force measured with Atomic Force Microscopy: Comparison of two chemical protocols for the tethering of single molecules”, Journal of Molecular Recognition, 24(5): 847-853, 2011.
E. Pagoulatou, I.E.Triantaphyllidou, D.H. Vynios, D.J. Papachristou, E. Koletsis D.Deligianni, D. Mavrilas. Biomechanics and structural changes following the decellularization of bovine pericardial tissues for use as a tissue engineering scaffold”.
J Mater Sci: Mater Med, 23(6);1387-96 (2012).
PA. Kokkinos, R Wright, PB. Kirby, AND DD. Deligianni, Differential Regulation of Osteoblasts by Microstructural Features of Titanium Substrata. Trends Biomater. Artif. Organs 26(1), 2012, 16-24.
PA. Kokkinos, PG Koutsoukos, and DD Deligianni, Detachment strength of human osteoblasts cultured on hydroxyapatite with various surface roughness. Contribution of integrin subunits. J Mater Sci Mater Med, 23(6) (2012), 1489-1498.
Patents:
European Patent Office:
Membranes made from P(AN/NVP)-copolymers with both haemo and tissue compatibility and their application in medical field.
Inventors: GKSS (Berlin): Albrect, Groth, Malsh, Seifert, University of Patras: Michanetzis, Missirlis, Free University of Berlin: Fey-Lamprecht, Gross, Strathclyde University: Courtney, Grant, Holland Biomaterials Group: Engbers
Greek Industrial Property Organization:
Description of a method to attach liposomic forms of heparin and/or other biomolecules on polymeric surfaces in order to control the release of their active substance(s) Inventors: Missirlis I, Antimisiaris S, Koromila G and Michanetzis G.
Equipment
Equipment facilities include
Atomic Force Microscope (Veeco) / Nanoindemtation (Hysitron) system, Scanning Electron Microscope, Confocal / Epifluorescent Microscope (Nikon) (3 channels+transmission), clean room / cell culture facilites, mechanical testing devices, PCR, centrifuges, deep freezer, plate readers, …
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