Antonis’ interests lie in the understanding of the pathophysiology of diseases, organs and systems using computational approaches, digital twins, and simulations. His work focuses on the development of multi-scale models combining 3D mechanistic modelling approaches with artificial intelligence and machine learning. His aim is to integrate such models into decision support systems for the clinical practice. Major part of his part work regards the computational modelling of the atherosclerotic plaque development.

Antonis I. Sakellarios has published over 45 journal articles, 100 conference papers, 1 book and 4 book chapters. He participated as a researcher in European and National projects related to atherosclerosis, heart failure, stent deployment, and other. He received fellowship grants from the Hellenic Cardiology Society and the European Atherosclerosis Society.